Coastal Research Institute was founded by physicians with a focus on patient outcomes and community relationships. We offer multi-disciplinary services for clinical research including experimental design, study execution, data analysis, publication and podium.

 

UPCOMING EDUCATIONAL EVENT

EMPOWER YOU: The Patient Centric Conference

Presented by Coastal Research Institute

 

August 26, 2023

Town & Country, San Diego, CA

Course Director: Krishnan Chakravarthy, M.D., Ph.D.

Coastal Research Institute is launching its first patient facing, chronic pain conference “EMPOWER YOU” specializing in pain therapy options & education.

EMPOWER YOU features the following:

  • A high focus on patients and their ability to understand their options.

  • A landmark moment for its growing specialty using evidence based approaches to educate primary care providers, caregivers, and patients.

  • An agenda packed with educational sessions and product theaters.

 
 

Publications

Research

Chronic Pain and Small Molecule Drug  Development

The Chakravarthy laboratory is currently working with the pharmaceutical company Eisai Pharmaceuticals, as well as the National Institute of Health, to develop novel small molecule therapies to treat chronic pain.  This includes targeting Toll-Like Receptor 4 and Kindolor, which acts as an inhibitor of the pain propagating Nav1.7 and Nav1.8 sodium channels and as an inhibitor of NMDA receptors that act to magnify pain signals.  

Nanomedicine

The Chakravarthy laboratory is working with the UCSD Department of NanoEngineering to advance a new microneedle-based transdermal drug delivery of pain medications and efficient vaccine delivery.  This approach overcomes the deficiencies of using hypodermic needles, which have served as the primary strategy for vaccine and medication delivery, but inflict pain, incite extreme fear in varying degrees (reducing compliance), and are the causative factor in injury and infection. In addition, there is a pressing need for rapid deployment for vaccine and drug delivery and less use of medical and staff resources to achieve that delivery.    

Neuromodulation

Physicians in the United States have been using spinal cord stimulation (SCS) to treat chronic pain conditions since it was first developed nearly half a century ago. Inspired by the seminal gate-control theory of pain proposed by Melzack and Wall, the conventional paradigm of SCS utilizes tonic 40-60 Hz stimulation that activates dorsal columns to elicit paresthesia over a patient’s painful region. This paresthesia-based SCS has proven to be an effective treatment modality for 40-50% of patients with refractory pain conditions, including complex regional pain syndrome and failed back surgery syndrome (FBSS). However, conventional SCS has several limitations, such as limited clinical indications, suboptimal or inadequate pain inhibition (e.g., non-responders), and progressive reduction of treatment effects over time.  The Chakravarthy Laboratory in collaboration with UCSD Nanoengineering laboratory is developing new paradigm-shifting neuromodulation technology and spinal cord stimulation devices.  We are also actively involved in several ongoing clinical trials with industry partners.  

 
 

Clinical Trials

If you are interested in joining any of the following clinical trials, kindly contact our clinical research manager, Suzanne Nanson:


Bioventus Peripheral Nerve Registry

A Prospective, open-label, long-term, multi-center, registry to assess the safety and efficacy of the Bioness StimRouter Neuromodulation system in subjects with chronic pain of peripheral nerve origin.

Study Sponsored Registry with Vivex Biologics

Single center registry study focusing on using ViaDisc as an non-surgical treatment option for supplementing degenerated intervertebral discs. VIA Disc is an allogeneic disc tissue matrix injected into the center of the nucleus pulposus of a painful disc in a convenient and safe outpatient setting.

Study Sponsored by Rune Labs

A validation of evoked compound action potentials as an ancillary biomarker for multiple sclerosis induced demyelination and pain. A feasibility study that is an open-label study to assess the presence of data in the ECAP signal that is measured by a spinal cord stimulation (SCS) device which may correlate with demyelination in Multiple Sclerosis patients.

Study Sponsored by Mainstay Medical

The RESTORE study will compare Optimal Medical Management (OMM) to the Reactiv8 System in a prospective randomized study. This treatment will target intractable mechanical chronic low back pain. Optimal Medical Management is managed according to current guideline treatments, including medication, physical therapy, and injection. Reactiv 8 therapy is an implantable electrical stimulation system that is initiated manually by an external device.

Studies Sponsored by Abbott

DISTINCT: the Dorsal spInal cord STImulation vs mediCal management for the Treatment of low back pain (DISTINCT study) is a prospective, multicenter, randomized, controlled, post market trial. It is designed to evaluate the efficacy of BurstDR SCS compared to conventional medical management in the treatment of chronic low back pain including neuropathic pain. We are currently following up with our patients on this study and not enrolling any new patients.

T2P: Spinal Cord Stimulation trial to Permanent Prediction (SCS T2P) is a prospective, longitudinal, multi-center, non-randomized, dual arm, open-label, clinical feasibility study. This study investigates whether objective data (wearable sensors) collected from chronic pain patients coincides with the subjective patient-reported outcomes (PROs) and adjustments with SCS device.

Studies Sponsored by Medtronic

PSTM: the registry is designed to conduct non-randomized, active prospective post-market surveillance. The registry design is patient-centric and follows a single patient receiving therapy from the spinal cord stimulator.

TDD: the registry is designed to conduct non-randomized, active prospective post-market surveillance. The registry design is patient-centric and follows a single patient receiving therapy from the targeted drug delivery.

Echo-MDT: electrically evoked compound action potentials human observation Medtronic system study (ECHO-MDT). This is a prospective, multi-center, nonsignificant risk IDE study of non-evoked and evoked waveforms resulting from stimulation of the dorsal column using a closed-loop system comprised of Medtronic hardware or OTS hardware, which uses recorded waveforms to adjust stimulation amplitude.

Studies Sponsored by Boston Scientific

Envision: a prospective, post-market, multi-center study whose objective is to characterize the relationship between select objective metrics and clinical outcomes in chronic pain patients treated with Boston Scientific commercially approved neurostimulation systems and may use observed relationships to make recommendations.

Scope: a prospective, multicenter, single-arm observational post-approval study to compile real-world outcomes of the Superion IDS in routine clinical practice. The Superion IDS is intended to treat skeletally mature patients suffering from pain, numbness, and/or cramping in the legs (neurogenic intermittent claudication) secondary to a diagnosis of moderate degenerative lumbar spinal stenosis.

 Faculty/Sites

Dr. Gemayel Lee, M.D., is double board certified in anesthesiology and interventional pain medicine. He is a co-founder and CEO of Relive You, Center for Advanced Pain Management in San Diego, CA. His interests include neuromodulation with a focus on peripheral nerve stimulation, patient education and practice management.

Dr. Brittany Grovey, M.D., is double board certified in anesthesiology and pain medicine. She is a co-founder and interventional pain management physician with Relive You Center for Advanced Pain Management in San Diego, CA. In addition to interventional pain management, her interests include value based care, improving access to care, and remote physiologic and therapeutic monitoring.

Dr. Michael Verdolin, M.D., is a 1996 graduate of the University of Miami School of Medicine in Florida. Dr. Verdolin completed an anesthesiology residency at the National Naval Medical Center in Bethesda, Maryland, and Walter Reed Army Medical Center in Washington, D.C. He served as an anesthesiologist and treated acute pain aboard the USNS Comfort during the most recent Gulf war. He then received fellowship training in interventional pain management at Walter Reed Army Medical Center. Dr. Verdolin transferred to the Naval Medical Center in San Diego where he served as chief of pain management from 2006 to 2007 before leaving the U.S. Navy in 2007.

He holds multiple academic positions, serving as an assistant professor of anesthesiology at the Uniformed University of the Health Sciences in Bethesda and has served as clinical faculty for the Scripps Mercy Internal Medicine Residency. His other activities include serving as a guest reviewer for Pain Medicine and authoring journal articles on pain care topics, including the use of neuromodulation. He has pioneered use and application of ultrasound guidance in both regional anesthesia and pain medicine.

He practices in San Diego focusing on interventional pain management, actively participates in sponsored research, and hosts a GME approved rotation for Navy Pain Medicine Fellows as owner of Pain Consultants of San Diego.

Dr. Nathaniel Schuster, M.D., is a Pain and Headache Neurologist at the UC San Diego Center for Pain Medicine, where he serves as Associate Clinic Director. He is Executive Vice President of the World Headache Society, recipient of the Migraine Research Foundation’s 2018 Impact Award research grant, 1 of 32 speakers at the 2022 Migraine World Summit, and section editor for the Neuropathic Pain section for the journal Pain Medicine.

Dr. Perrizo’s (M.D) unique and diverse background adds to the comprehensiveness of services provided at Pacific Pain Medicine Consultants. His career as a physician in California has been augmented by specialized training in osteopathy. Following his internship, he entered the United States Navy and served as a Medical Officer on USS NASSAU in Operation Iraqi Freedom.

He ultimately advanced to Senior Medical Officer of USS CARTER HALL where he was the sole medical officer for hundreds of service members. He had the critical responsibility to coordinate with the Commanding Officer when a crew members’ health superseded the ship’s mission.

After completion of his military service, Dr. Perrizo completed a residency in Physical Medicine and Rehabilitation at UCLA. He further specialized by taking a fellowship in Interventional Pain Management at UCLA, which included mentoring under internationally recognized experts in the field of pain management.

Dr. Perrizo is board certified in Physical Medicine and Rehabilitation and has subspecialty certification in Pain Medicine. He has special expertise in a variety of procedures including spinal cord stimulation, radiofrequency neurotomy, and fluoroscopically/ultrasound guided injections.

Dr. Perrizo is a wonderful teacher and has lectured in international forums. He spends time with patients educating them about their conditions and thoroughly discusses the various treatments that may be available for them. He also serves as a mentor for other physicians in cutting edge medical treatments and procedures. Dr. Perrizo further provides expert consulting to industry for expanded access to current treatments and guidance on the development of novel therapies.

Dr. Choll Kim, M.D., Ph.D., a Harvard Graduate, now a Double-Board Certified Minimally Invasive Spine Surgeon. Dr. Kim is Internationally Recognized as an Expert in the field of computer assisted Minimally Invasive Spine Surgery as well as a World Leader in Laser Endoscopic Spine Surgery (LESS).
Through these state-of-the-art Minimally Invasive treatments, Dr, Kim effectively treats all aspects of complex spinal disorders, including herniated discs, annular tears, radiculopathy, sciatica, and spondylolisthesis.
Dr. Kim prides himself in treating his patients like family and providing concierge style medicine to ensure his patients receive the most appropriate treatment plan to regain their quality of life as soon as possible.

Dr. Lee, M.D., was fellowship trained in Interventional Spine at The Orthopedic Clinic Association (TOCA) in Phoenix, Arizona. He completed his residency training at the State University of New York (SUNY), Downstate and is Board Certified in Physical Medicine & Rehabilitation (PM&R) and Pain Medicine.

He is graduated from the Chicago Medical School after obtaining degrees in both Biochemistry and English. He remains an active member in multiple medical organizations including the American Academy of Physical Medicine & Rehabilitation (AAPMR), Orange County Medical Association, Spine Interventional Society (SIS) and North American Neuromodulation Society (NANS). He is presently Chair of the AAPMR Clinical Practice Guidelines Committee. He serves as a Board Member for the American Society of Pain and Neuroscience (ASPN) and Pacific Spine and Pain Society (PSPS). He reviews manuscripts for the Regional Anesthesia & Pain Medicine, Pain Medicine and PM&R Journals; and is a running member of the Credentialing Committee for the American Board of Pain Medicine.

Dr. Lee specializes in non-surgical treatment of both neck and back pain through the use of epidurals, facet joint injections, sacroiliac joint injections, radiofrequency neurotomy, vertebroplasty/kyphoplasty, discography, spinal cord stimulator trials/implants, non-surgical scoliosis evaluation and management. 

Dr. Lee has provided sports coverage from high school to the professional level in a wide variety of sports including football, hockey, baseball and basketball. He has had the opportunity to work with the NBA team Phoenix Suns, WNBA team Phoenix Mercury and Arizona State University (ASU) while in fellowship. He serves as a Spine Consultant for the USA Volleyball Team. He volunteers as the Team Physician for Esperanza High School Football Program.

Dr. Munish Lal, M.D., interventional pain management physician serving patients in South Bay Los Angeles, Redondo Beach, Torrance, and Newport Beach, Orange County, California. Dr. Lal completed medical school at Jawaharlal Nehru Medical College in Belgaum, India followed by internship with a residency at Delhi Hindu Rao Hospital. Shortly after Dr Lal moved to Jersey City to do his Internship at Jersey City Medical Center. Then Dr Lal completed his residency in Anesthesiology at University of Cincinnati. He supplemented his training with a fellowship in spine and interventional pain management at The University of Texas M.D. Anderson Cancer Center. His subspecialty in pain medicine involves the use of rehabilitative techniques and minimally invasive interventional procedures to manage spine and pain disorders.

With over 18 years of experience, Dr. Munish Lal specializes in the use of minimally invasive state-of-the-art techniques to treat spinal pain that include intervention procedures ( MILD, Vertiflex, SI Joint Fusion, Intracept, Kyphoplasty, Minute-Man procedure, Spinal Cord Stimulation, DRG Stimulation, Peripheral Nerve Stimulation, Radio Frequency, Thermocoagulation, Platelet-rich plasma therapy ) and a comprehensive array of traditional pain management services.

Dr. Seth Katzen, M.D., is the double board-certified interventional spine and pain physician at Girard Orthopaedic Surgeons in San Diego, California. He completed subspecialty training at the ACGME accredited interventional pain management fellowship program at UC San Diego in the Department of Anesthesiology. Prior to this, Dr. Katzen completed residency training in the specialty of Physical Medicine and Rehabilitation (PM&R) at Washington University in St. Louis School of Medicine, where he served as the Administrative Chief Resident. 

Dr. Katzen is passionate about the field of pain medicine and optimizing the treatment of acute and chronic pain conditions utilizing a multidisciplinary approach along with the most cutting-edge pain management techniques. He specializes in a wide array of advanced neuromodulation and minimally invasive procedures to treat painful conditions. Dr. Katzen is interested in forging advances in the areas of interventional pain and musculoskeletal medicine through involvement in academic research-having published and presented several studies and cases nationally and internationally.  He is a native San Diegan and strives to provide the best care for the people of his home community.

 Solutions

 

CRI Research Standard of Excellence

  • Industry, and NIH funded clinical trial institute

  • Focused on small molecule, medical device development

  • Distinguished clinical partnership with Coastal Pain and Spinal Diagnostics

  • In-house toxicology laboratory for potential biomarker analysis

  • 10,000 square foot Ambulatory Surgery Center for Clinical Work

  • New IP creation for potential licensing opportunities

  • Digital Services with a focus on objective outcomes measures

  • Center of Excellence Development for physician training

  • Industry driven pre-clinical and clinical trials research

  • Quality, relevant and compliant study participant selection

  • Good Clinical Practices

Leadership

President, Executive Director of Institute

Dr. Krishnan Chakravarthy M.D., Ph.D. has >100 papers published; >50 abstracts; >300 regional, national, and international talks; National/International Award Winner in Pain Medicine; International Thought Leader in Pain Space. He serves on the board of the major pain companies and sits on the editorial board of several national and international journals. He completed his residency at the Johns Hopkins Hospital, and pain fellowship at Harvard/Massachusetts General Hospital. He also sits on the executive board and committees of the major pain societies such as American Society of Pain and Neuroscience. Expertscape's PubMed-based algorithms placed Dr. Chakravarthy in top 0.1% of scholars writing about Pain Management over the past 10 years defining him as a "World Expert.” He has been involved in pioneering several first clinical cases in the United States and has been a founding faculty member of “Restorative Neurostimulation”. To date he has raised >9 million in direct and and indirect funding and launched multiple startups from his research work that are taking paradigm shifting technologies to market.

Director of Institute Operations/Business Development

Dr. Nathan A. Miller, M.D. is a pioneer in the field of pain medicine with over a decade of experience treating patients in the North County San Diego area. Dr. Nathan Miller is a well-respected, compassionate physician who strives to help his patients regain their lives. He is Chief of Pain Medicine at Scripps Memorial Hospital, Encinitas and is double-board certified in Anesthesiology and Interventional Pain Medicine. Dr. Miller completed his pain fellowship at the prestigious University Of Virginia pain program. He is a diplomat of the National Board of Medical Examiners and a Qualified Medical Examiner in the State of California. Dr. Miller is at the forefront in the treatment and management of a wide variety of acute and chronic pain disorders. He is a strong proponent of a multi-disciplinary approach in pain management to improve outcome and increase quality of life. With his knowledge and the use of advanced medicine, he has been able to help many patients who had little hope of a functional life.

Consultant

Dr. Moleen Madziva, Ph.D., is an award-winning leader with over 12 years experience in medical devices Clinical Research. She’s a trained Electrical, Computer and Software Engineer with extensive R&D experience whose notable contributions led to the IDE approval of the Angelmed Guardian heart monitoring device in 2018. Her clinical science work in chronic pain and neurological disorders at Abbott led to publications of post market clinical evidence for several implantable devices. Her growing expertise in Artificial Intelligence positions her as a highly sort out Clinical Affairs Advisor since cost of running clinical trials hinges on speed of quality enrollment. She is dedicated to Clinical Research because of its capacity for bridging innovation with access to lifesaving treatments for patients. Beyond her leadership roles in Clinical Affairs, Dr. Madziva also serves as mentor and advisor to students and young professionals in STEM because she’s keenly aware of the need, particularly among women of color who do not see themselves widely represented in this industry. She’s well respected among her peers and brings inspiration and joy to everyone she meets.

Director of International Outreach

Dr. Dan Bates, M.D. is a Sports and Exercise Medicine Specialist. He is the Managing Director at Metro Pain Group and Metro Pain Research Institute and is the Chairman of the Board at Moans House Private Hospital.

Dr Bates works full time with people suffering back, neck and joint pain. Prior to this he worked extensively in Sports Medicine for multiple professional and national sporting teams. He was the head doctor at Australian Football League teams Melbourne and North Melbourne.

Dr Bates’ research career has been broad covering exercise induced asthma, examination techniques, biologics, osteoarthritis, chronic pain and neuromodulation. He is the Managing Director of Metro Pain Research Institute which runs multiple first-in-man studies in pain.

He lectures nationally and internationally regularly, has 3 kids and the worlds most tolerant wife.

Director of Clinical Operations and Outreach

Yogesh V. Patel, M.D. (“Dr. Yogi Patel”) has dedicated his life to the eradication of pain. Dr. Yogesh Patel practices evidence based medicine and the multi-disciplinary approach to pain management, giving his patients the most options and the best care possible. He has helped many patients with difficult and advanced debilitating pain conditions. Dr. Patel is double board certified in Anesthesiology and Interventional Pain Medicine from the American Board of Anesthesiology. Dr. Patel is admired by his colleagues and adored by his patients. Dr. Patel trained at UCSD, one of the highest rated interventional pain fellowship programs in the country. Dr. Patel is the founder of MyPainTools, a chronic pain education and prevention program. He feels that knowledge is empowerment, and that educated patients have the best chance for a pain-free lifestyle. Along with MyPainTools, he is actively developing programs to bring support groups and community education opportunities to North County. Dr. Patel has also worked extensively with other physicians and has placed strong emphasis on developing a strong working relationship with referring physicians with the end result of providing excellent and timely patient care.

Treasurer

Dr. Ankush Bansal, M.D., is a double board-certified Anesthesiologist and Interventional Pain Physician (through the American Board of Anesthesiology) that has devoted his career to understanding complex and difficult-to-treat painful conditions. He has helped numerous patients with incapacitating pain improve their quality of life and regain function. He is actively involved in ongoing clinical research and multiple national medical societies including American Society of Interventional Pain Physicians, American Society of Regional Anesthesia, and North American Neuromodulation Society. He has published articles in peer-reviewed medical journals including the Pain Medicine Journal. He is continually striving to find new and effective ways to treat chronic pain. He completed his Doctor of Medicine (MD) at the University of Michigan Medical School. After enduring a chronic painful neck injury, he moved to Los Angeles to specialize in Anesthesiology and Chronic Interventional Pain Management through the University of California Los Angeles (UCLA) where he was mentored by some of the most renown figures in the field of Pain Medicine.

 

Staff

Executive Assistant

Missy Medeiros

Clinical Research Coordinator

Yessenia Valencia

Senior Clinical Research Coordinator

Suzanne Nanson joined us at Coastal Pain in 2015 as Clinical Research Coordinator. Suzanne has been in the medical field for 31 years and has been a Clinical research coordinator for the last 20 years. Suzanne’s background was Rheumatology until joining the Coastal Pain team, and she is loving the transition to Pain management. Suzanne has managed clinical trials from phase 1- 4 and all aspects of clinical trials from start up to close out. Her focus is always benefits to the patient, and puts patient care as a top priority.

Suzanne and her husband relocated from Scottsdale AZ after 20 years to return back home to CA 2015 be closer to their family. She enjoys spending her free time with her husband, family, including grandbabies, & friends. She loves to travel, and a day at the beach ending with a sunset is always a great day.

Post Doctoral Fellow

Stephanie Caro is a current 4th-year medical student at the California University of Science and Medicine. She is a graduate student researcher working under the supervision of Dr. Chakravarthy. Before medical school, she worked as a medical scribe at a community clinic for the underserved and as a behavioral interventionist for children with Autism Spectrum Disorder. Stephanie completed her undergraduate degree in Psychology with a minor in Applied Psychology at the University of California, Santa Barbara, and a Pre-medical post-baccalaureate at San Francisco State University. After completing her research year, she plans to apply for a residency, specializing in anesthesiology. Stephanie currently lives in San Diego and enjoys reading fiction and comics, taking part in outdoor activities, and playing video games.

Head of Clinical Research International

Dr. Maja Green, Ph.D., MBA, is currently appointed as the Head of Research at Metro Pain Research Institute. Despite her many years of experience in clinical research and having the opportunity to work on solving various health issues, Dr Green believes that exploring novel therapies to treat chronic pain is pressing and vital.

Prior to working in the chronic pain field, Dr Green accumulated a multitude of achievements and awards, authoring several publications in high-impact journals and presenting her findings at national and international conferences.

Some of Dr Green’s previous clinical research experiences lie in Critical Care and Oncology. Prior to her current appointment, Dr Green’s research focused on helping older people in our community to maintain independence and well-being. Dr Green completed her Ph.D. in Biochemistry, La Trobe University and Royal Children’s Hospital, elucidating mechanisms of chemotherapy resistance in high-grade gliomas. Dr Green’s other areas of research include Oncology and Neuroscience.

Outreach and Head of Marketing

Jackie Ellis is a San Diego native with a versatile background in customer service, marketing, and the legal field. She truly enjoys helping people, and assisting patients as they navigate their treatment at Coastal. She graduated in 2014 with a BA in Marketing and Public Relations from Ashford University and joined Coastal in March 2020. In her spare time, she enjoys traveling down to Baja with her family, cuddling up with her two French bulldogs, and spending time with her friends at the beach or poolside.

Clinical Research Coordinator

Rylee Owen joined Coastal Research Institute in August of 2022. She has the background of working as a Scribe/Medical Assistant for Dr. Bansal at Coastal Pain and Spinal Diagnostics for 2 years, a Physical Therapist aid for 3 years as well as a Cross Country Coach. She is a San Diego native and received her Bachelors of Science, Biology degree from Point Loma Nazarene University. While attending Point Loma she had the wonderful opportunity of going abroad for a medical mission's trip in the Northern Villages of Thailand. She is an active CrossFit athlete and enjoys hiking in the mountains including summiting Mt. Whitney.

Institute Program Manager

Sean Taitt

 

Advisory Board

Dr. Timothy Deer, M.D. received his medical degree from the West Virginia University School of Medicine, and received his training in Anesthesiology and Pain Medicine at The University of Virginia. Dr. Deer is the President and Chief Executive Officer of The Spine and Nerve Center of the Virginias in Charleston, West Virginia. The Center focuses on pivotal research and the algorithmic application of Neuromodulation therapies to improve pain and function. Dr. Deer is the founder and Chairman of the American Society of Pain and Neuroscience and Immediate Past President of the International Neuromodulation Society (INS) and is President Emeritus of the West Virginia Society of Interventional Pain Physicians. Dr Deer is a past Chairman of the Pain Committee of the American Society of Anesthesiologists (ASA). He has published over 200 peer reviewed manuscripts, several book chapters and several widely used text books. Dr. Deer has taught interventional techniques throughout North America, South America, Australia, Asia, and Europe. He continues to focus on landmark research to advance the field of Neuromodulation. His latest book, Deer's Treatment of Pain is currently being used as an anchor of pain treatment information throughout the world.

 

Dr. Joseph Wang, Ph.D. is an American researcher and inventor. He is a Distinguished Professor, SAIC Endowed Chair, and former Chair of the Department of Nanoengineering at the University of California, San Diego specializing in nanomachines, biosensors, nano-bioelectronics, wearable devices, and electrochemistry. He also serves as the Director of the Center for Wearable Sensors at the University of California San Diego Jacobs School of Engineering.

 

Dr. Ricardo Vallejo, M.D., Ph.D. is the Director of Research at Millennium Pain Center. He is deeply committed to discovering new methods and treatments for chronic pain. Dr. Vallejo holds multiple appointments in the editorial boards of international peer review journals such as Clinical Journal of Pain, Pain Physicians, Journal of Opioid Management Revista Mexicana de Anestesiologia. Dr. Vallejo is the current Associate Editor of the journal Pain Practice, where he established the section Images in Pain Practice in 2007. He is also a member of the examination board for the World Institute of Pain. Dr. Vallejo has published extensively in national and international peer-review journals and serves as a speaker in meetings around the world. He is adjunct professor at the Illinois State University. Research interests of Dr. Vallejo include management of chronic pain status, such as sympathetically maintained pain: failed back surgery, and discogenic low back pain. His research efforts are aimed at understanding the immune mechanisms underlying neuropathic pain conditions and the effects of electrical stimulation on the central and peripheral immune response.

Startups

Douleur Therapeutics is a clinical-stage pharmaceutical company located in San Diego, CA, that is focused on revolutionizing the treatment of neuropathic pain. Our compound, DT-001, is a TLR-4 antagonist and has been shown to be safe in over 1500 patients. Our strategy is to apply DT-001 to Chronic Post-Operative Pain (CPOP). Extensive pre-clinical data indicate that overstimulation of TLR-4 can place the immune system into overdrive causing acute pain to transition into chronic pain. Other potential therapeutic areas are: joint pain, discogenic pain, chemotherapy-induced peripheral neuropathy, migraines, and the propagation of opioid-induced hyperalgesia pathway.

Newrom Biomedical aims to revolutionize the Neurostimulation paradigm using nanotechnology to achieve optimized patient-centric outcomes. We are a startup company located in San Diego, CA, specialized in next-generation spinal cord stimulation and dorsal root ganglion stimulation development.

Next Generation Stimulation Technologies (NXTSTIM) was founded by Dr. Krishnan Chakravarthy MD, PhD in 2020. NXTSTIM is an American neuromodulation & biotechnology company based in San Diego, California, United States. NXTSTIM designs & manufactures medical devices leveraging disruptive battery technology, AI & ML software platforms.

Creating a solution to a major problem in todays $2.6 billion global SCS marketplace. The issue of SCS trial lead migration effects every physicians practice knowingly or unknowingly. As an industry there is no consistency or continuity on how to anchor SCS Trial leads. Accufix Medical was founded to commercialize Stimfix as an Novel Anchoring Technology developed to address this issue.

Paravertebral Closed Loop Muscle Stimulator
First distributed in the 1960s, spinal cord stimulation (SCS) utilized artificially generated electricity to modulate human tissue that relied on electricity to propagate signals. Since then, a closed-loop system was developed which utilizes recorded evoked compound action potentials (ECAPs) to a fixed-output, open-loop system for patients with chronic back and leg pain. A self-adjusting SCS system can internally preserve optimal programming parameters while adapting to the patient’s experiences or activities. Closed-looped stimulation provides neuromodulators, for the first time ever, with the ability to objectively measure and interact with the spinal cord’s electrical activity, just like a cardiac pacemaker would with the heart. The implications of this concept are the most progress science has made in the potential for providing superior pain control with SCS.

News

2022

2021

Alumni

Farzan Vahedifard

Lakshmi Rekha Narra

Dr. Rajiv Reddy

Wathnita Sarik

Rahul Chaturvedi

 

 Careers

Please contact Dr. Chakravarthy:

Coastal Research Institute

6221 Metropolitan Street, Ste. 201

Carlsbad, CA 92009

phone: (760) 607-1729

 
 

Contact Us

We look forward to hearing from you. Please allow up to 1-2 business days for a response from one of our representatives.